News Update on Kidney Disease Research: Nov – 2019

 News Update on Kidney Disease Research: Nov – 2019

Definition and classification of chronic kidney disease: A position statement from Kidney Disease: Improving Global Outcomes (KDIGO)

Definition and classification of chronic urinary organ disease: a foothold statement from urinary organ Disease: up international Outcomes (KDIGO). Chronic uropathy (CKD) could be a worldwide public unhealthiness, with adverse outcomes of renal disorder, upset (CVD), and premature death. a straightforward definition and classification of uropathy is important for international development and implementation of clinical apply pointers. uropathy: up international Outcomes (KDIGO) conducted a survey and sponsored a controversies conference to (1) give a transparent understanding to each the medicine and nonnephrology communities of the proof base for the definition and classification suggested by urinary organ malady Quality Outcome Initiative (K/DOQI), (2) develop international accord for the adoption of a straightforward definition and organisation, and (3) establish a cooperative analysis agenda and arrange that will improve the proof base and facilitate implementation of the definition and classification of CKD. [1]

Polycystic Kidney Disease

Polycystic excretory organ diseases are transmissible nephritic disorders due primarily to mutations in genes that regulate the event and performance of cells that line renal tubules. This review outlines the clinical importance of polycystic excretory organ diseases and discusses the cell biology and molecular mechanisms that cause the formation of many cystic lesions within the nephritic parenchyma. [2]

Prevalence of Chronic Kidney Disease in the United States

Context: The prevalence and incidence of kidney disease treated by qualitative analysis and transplantation within the us have increased  from 1988 to 2004. whether or not there are changes within the prevalence of earlier stages of chronic nephropathy (CKD) throughout this era is unsure.

Objective: To update the calculable prevalence of CKD within the us.

Design, Setting, and Participants: Cross-sectional analysis of the foremost recent National Health and Nutrition Examination Surveys (NHANES 1988-1994 and NHANES 1999-2004), a across the country sample of noninstitutionalised adults aged twenty years or older in 1988-1994 (n = fifteen 488) and 1999-2004 (n = thirteen 233). [3]

Autosomal dominant tubulointerstitial kidney disease

Autosomal dominant tubulointerstitial renal disorder (ADTKD) may be a recently outlined entity that features rare urinary organ diseases characterised by hollow harm and opening pathology within the absence of capillary vessel lesions, with inevitable progression to end-stage urinary organ malady. These diseases have long been neglected and under-recognized, partially because of confusing and inconsistent nomenclature. The introduction of a gene-based, unifying nomenclature semiconductor diode to the identification of associate degree increasing range of cases, with recent information suggesting that ADTKD is one amongst the a lot of common heritable {kidney malady|renal disorder|nephropathy|nephrosis|uropathy}s when chromosome dominant polycystic urinary organ disease, accounting for ~5% of heritable disorders inflicting chronic renal disorder. [4]

Controversies in the Management of Early Stage Diabetic Kidney Disease

Diabetic nephrosis (DKD) may be a major and increasing worldwide public health concern as a result of it’s the leading reason behind end-stage nephritic disease (ESRD) and a high risk for vessel events. variety of interventions if initiated at associate early stage of DKD scale back the chance and slow the progression to ESRD. though vital improvement in management of DKD has been developed, there are sure problems that require to be mentioned.  The interventions and controversies in management of DKD are the main target of this presentation. varied international pointers and relevant literatures that were printed through Gregorian calendar month 2001 to June 2018 for the recommendations on the management of DKD were reviewed. the perfect glycaemic goal in DKD with calculable capillary vessel filtration rate (eGFR). [5]

Reference

[1] Levey, A.S., Eckardt, K.U., Tsukamoto, Y., Levin, A., Coresh, J., Rossert, J., Zeeuw, D.D., Hostetter, T.H., Lameire, N. and Eknoyan, G., 2005. Definition and classification of chronic kidney disease: a position statement from Kidney Disease: Improving Global Outcomes (KDIGO). Kidney international, 67(6), (Web Link)

[2] Wilson, P.D., 2004. Polycystic kidney disease. New England Journal of Medicine, 350(2), (Web Link)

[3] Coresh, J., Selvin, E., Stevens, L.A., Manzi, J., Kusek, J.W., Eggers, P., Van Lente, F. and Levey, A.S., 2007. Prevalence of chronic kidney disease in the United States. Jama, 298(17), (Web Link)

[4] Autosomal dominant tubulointerstitial kidney disease
Olivier Devuyst, Eric Olinger, Stefanie Weber, Kai-Uwe Eckardt, Stanislav Kmoch, Luca Rampoldi & Anthony J. Bleyer
Nature Reviews Disease Primers volume 5, Article number: 60 (2019) (Web Link)

[5] Ahmed, S. S. (2018) “Controversies in the Management of Early Stage Diabetic Kidney Disease”, Journal of Advances in Medicine and Medical Research, 27(8), (Web Link)

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