Latest Research News on Prevalence of Hepatitis: Dec – 2019

The Prevalence of Hepatitis C Virus Infection in the United States, 1988 through 1994

BACKGROUND: Because many persons with chronic hepatitis C virus (HCV) infection are asymptomatic, population-based serologic studies are needed to estimate the prevalence of the infection and to develop and evaluate prevention efforts.

METHODS: We performed tests for antibody to HCV (anti-HCV) on serum samples from 21,241 persons six years old or older who participated within the third National Health and Nutrition Examination Survey, conducted during 1988 through 1994. We determined the prevalence of HCV RNA by means of macromolecule amplification and therefore the genotype by means of sequencing. [1]

Global distribution and prevalence of hepatitis C virus genotypes

Hepatitis C virus (HCV) exhibits high genetic diversity, characterized by regional variations in genotype prevalence. This poses a challenge to the improved development of vaccines and pan‐genotypic treatments, which require the consideration of worldwide trends in HCV genotype prevalence. Here we offer the primary comprehensive survey of those trends. To approximate national HCV genotype prevalence, studies published between 1989 and 2013 reporting HCV genotypes are reviewed and combined with overall HCV prevalence estimates from the worldwide Burden of Disease (GBD) project. We also generate regional and global genotype prevalence estimates, inferring data for countries lacking genotype information. We include 1,217 studies in our analysis, representing 117 countries and 90% of the worldwide population. [2]

The Prevalence of Hepatitis C Virus Infection in the United States, 1999 through 2002

Background: Defining the first characteristics of persons infected with hepatitis C virus (HCV) enables physicians to more easily identify persons who are presumably to profit from testing for the disease.

Objective: to explain the HCV-infected population within the us.

Design: Nationally representative household survey.

Setting: U.S. civilian, noninstitutionalized population.

Participants: 15 079 participants within the National Health and Nutrition Examination Survey between 1999 and 2002. [3]

Prevalence of hepatitis E infection in HIV/HCV-coinfected patients in Spain (2012–2014)

Hepatitis E virus (HEV) has emerged as a relevant pathogen for HIV-infected patients. However, there’s scarce data on HEV infection in HIV/HCV-coinfected individuals with advanced fibrosis, which seems to extend the danger of HEV infection and worsen the prognosis of disease. We aimed to work out the prevalence of anti-HEV antibodies, acute hepatitis E, resolved hepatitis E, and exposure to HEV in HIV/HCV-coinfected patients and to guage associations with clinical and epidemiological characteristics. We performed a cross-sectional study on 198 HIV/HCV-coinfected patients, 30 healthy controls and 36 HIV-monoinfected patients. [4]

Prevalence of Hepatitis B among Food Vendors in Wurukum Market, Makurdi Benue State

Hepatitis B may be a life threatening infectious disease caused by hepatitis B virus (HBV). The aim of this study was to work out the prevalence of HBV among food vendors in Wurukum, a highly commercial section of metropolitan Makurdi in Benue State. The test was administered with the utilization of an immunochromatographic  micropoint HBsAg test strips and a HBsAg  buffer screen for the virus. Out of the 250 non-vaccinated food vendors sampled, 27(10.8%) had HBV infection, with more in males (21.7%) than in females (6.6%). No significant difference (p>0.05) was found among age groups in spite of the observed highest prevalence of 14.3% among the 20-29 year olds. Therefore, the necessity for routine screening can’t be overemphasized in spite of known risk factors among food vendors. [5]

Reference

[1] Alter, M.J., Kruszon-Moran, D., Nainan, O.V., McQuillan, G.M., Gao, F., Moyer, L.A., Kaslow, R.A. and Margolis, H.S., 1999. The prevalence of hepatitis C virus infection in the United States, 1988 through 1994. New England journal of medicine, 341(8), (Web Link)

[2] Messina, J.P., Humphreys, I., Flaxman, A., Brown, A., Cooke, G.S., Pybus, O.G. and Barnes, E., 2015. Global distribution and prevalence of hepatitis C virus genotypes. Hepatology, 61(1), (Web Link)

[3] Armstrong, G.L., Wasley, A., Simard, E.P., McQuillan, G.M., Kuhnert, W.L. and Alter, M.J., 2006. The prevalence of hepatitis C virus infection in the United States, 1999 through 2002. Annals of internal medicine, 144(10), (Web Link)

[4] Prevalence of hepatitis E infection in HIV/HCV-coinfected patients in Spain (2012–2014)
Sonia Vázquez-Morón, Juan Berenguer, Juan González-García, Ma Ángeles Jiménez-Sousa, Isabel Canorea, Josep M. Guardiola, Manuel Crespo, Carmen Quereda, José Sanz, Ana Carrero, Victor Hontañón, Ana Avellón & Salvador Resino
Scientific Reports volume 9, (Web Link)

[5] Obisike, V. U., Uke, C. M. and Amuta, E. U. (2018) “Prevalence of Hepatitis B among Food Vendors in Wurukum Market, Makurdi Benue State”, South Asian Journal of Research in Microbiology, 2(3), (Web Link)

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