Latest Research News on Cytotoxic Effect : March-2020

Selective cytotoxic effect of ZnO nanoparticles on glioma cells

In this study we examined the cytotoxic effect of ZnO nanoparticles on various human cancer and normal cells. We found that the ZnO nanoparticles exerted a cytotoxic effect on the human glioma cell lines A172, U87, LNZ308, LN18, and LN229, whereas no cytotoxic effect was observed on normal human astrocytes.  [1]

Preparations of lymphotoxin induce resistance to their own cytotoxic effect.

Preparations of human lymphotoxins (LT) were effectively cytotoxic to HeLa cells when applied in the presence of cycloheximide (CHI). In the absence of CHI, however, they failed to cause any cell death. [2]

Cytotoxic Effect of Brain Macrophages on Developing Neurons

Brain macrophages are transiently present in different regions of the central nervous system during development or in the course of tissue remodelling following various types of injuries. To investigate the influence of these phagocytes on neuronal growth and survival, brain macrophages stemming from the cerebral cortex of rat embryos were added to neuronal primary cultures [3]

Investigation of Antioxidant Activity and Cytotoxic Effect of Stem of Anthocleista djalonensis

Aim: To investigate the antioxidant and cytotoxic activities of stem of A. djalonensis.

Study Design: The study assessed the antiradical potential of the stem bark of A. djalonensis and determined the cytotoxic effect of the plant extracts using Allium cepa root growth inhibition and Brine Shrimp lethality assays. [4]

Cytotoxic Effect and Chemical Composition of Inula viscosa from Three Different Regions of Morocco

Aims: Worldwide, growing interest was given to find new cytotoxic agents that could be used in breast cancer treatment. In this context, we have planned to evaluate cytotoxic activity of Inula viscosa extracts, on two breast cancer cell lines. The plant was harvested in three different regions of Morocco; Imouzzer, Tounate and Sefrou. [5]

Reference

[1] Ostrovsky, S., Kazimirsky, G., Gedanken, A. and Brodie, C., 2009. Selective cytotoxic effect of ZnO nanoparticles on glioma cells. Nano Research2(11), pp.882-890.

[2] Wallach, D., 1984. Preparations of lymphotoxin induce resistance to their own cytotoxic effect. The Journal of Immunology132(5), pp.2464-2469.

[3] Théry, C., Chamak, B. and Mallat, M., 1991. Cytotoxic effect of brain macrophages on developing neurons. European Journal of Neuroscience3(11), pp.1155-1164.

[4] C. Ogundare, O., M. Akoro, S., O. Ogunfowora, A. and Oladunni, A. (2017) “Investigation of Antioxidant Activity and Cytotoxic Effect of Stem of Anthocleista djalonensis”, European Journal of Medicinal Plants, 20(1), pp. 1-8. doi: 10.9734/EJMP/2017/33803.

[5] Messaoudi, M., Chahmi, N., El Mzibri, M., Gmouh, S., Amzazi, S., Benbacer, L. and El Hassouni, M. (2016) “Cytotoxic Effect and Chemical Composition of Inula viscosa from Three Different Regions of Morocco”, European Journal of Medicinal Plants, 16(4), pp. 1-9. doi: 10.9734/EJMP/2016/28340.

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