Latest Research News on Cervical Cancer: Jan – 2020

Cervical cancer

Cervical cancer may be a serious ill health , with nearly 500 000 women developing the disease annually worldwide. Most cases occur in less developed countries where no effective screening systems are available. Risk factors include exposure to human papillomavirus, smoking, and immune-system dysfunction. most girls with early-stage tumours are often cured, although long-term morbidity from treatment is common. Results of randomised clinical trials have shown that for ladies with locally advanced cancers, chemoradiotherapy should be considered the quality of care; however, the applicability of this treatment to women in less developed countries remains largely untested. many ladies with localised (stage IB) tumours even now receive various combinations of surgery and radiotherapy, despite unresolved concern about the morbidity of this approach compared with definitive radiotherapy or radical surgery. [1]

Prevalence of Human Papillomavirus in Cervical Cancer: a Worldwide Perspective

Background: Epidemiologic studies have shown that the association of genital human papillomavirus (HPV) with cervical cancer is robust , independent of other risk factors, and consistent in several countries. There are quite 20 different cancer-associated HPV types, but little is understood about their geographic variation.

Purpose: Our aim was to work out whether the association between HPV infection and cervical cancer is consistent worldwide and to research geographic variation within the distribution of HPV types. [2]

Human papillomavirus and cervical cancer

Cervical cancer is that the second commonest cancer in women worldwide, and knowledge regarding its cause and pathogenesis is expanding rapidly. Persistent infection with one among about 15 genotypes of carcinogenic human papillomavirus (HPV) causes most cases. There are four major steps in cervical cancer development: infection of metaplastic epithelium at the cervical transformation zone, viral persistence, progression of persistently infected epithelium to cervical precancer, and invasion through the basement membrane of the epithelium. Infection is extremely common in young women in their first decade of sexual intercourse . Persistent infections and precancer are established, typically within 5–10 years, from but 10% of latest infections. [3]

The novel circCLK3/miR-320a/FoxM1 axis promotes cervical cancer progression

As a replacement class of non-coding RNA, circular RNAs (circRNAs) play crucial roles within the development and progression of varied cancers. However, the detailed functions of circRNAs in cervical cancer have seldom been reported. during this study, circRNA sequence was applied to detect the differentially expressed circRNAs between cervical cancer tissues and adjacent normal tissues. The relationships between circCLK3 level with clinicopathological characteristics and prognosis were analyzed. In vitro CCK-8, cell count, cell colony, cell wound healing, transwell migration and invasion, and in vivo tumorigenesis and lung metastasis models were performed to guage the functions of circCLK3. [4]

Dynamics of Factors Responsible for the Resurgence of Cervical Cancer Lesions in Women in Developing Countries

Cervical cancer may be a major public ill health worldwide and it remains one among the foremost common malignancies of girls . the aim was to work out , factors liable for the upsurge of the uterine cells lesions observed on Pap smear abnormalities among Cameroonian women. to realize our goals, the present study was administered in three regions of Cameroon: South, Far North and Center Region for a period of two years. it had been a cross sectional and descriptive study. Analyses of samples collected were performed at the biological laboratory of every hospital. All women aged 18 to 65, with sexually active were included in our study. Principal techniques used were the traditional Papanicolau staining method. [5]

Reference

[1] Waggoner, S.E., 2003. Cervical cancer. The Lancet, 361(9376), (Web Link)

[2] Bosch, F.X., Manos, M.M., Muñoz, N., Sherman, M., Jansen, A.M., Peto, J., Schiffman, M.H., Moreno, V., Kurman, R. and Shan, K.V., 1995. Prevalence of human papillomavirus in cervical cancer: a worldwide perspective. JNCI: Journal of the National Cancer Institute, 87(11), (Web Link)

[3] Schiffman, M., Castle, P.E., Jeronimo, J., Rodriguez, A.C. and Wacholder, S., 2007. Human papillomavirus and cervical cancer. The Lancet, 370(9590), (Web Link)

[4] The novel circCLK3/miR-320a/FoxM1 axis promotes cervical cancer progression
Hanqing Hong, Hai Zhu, Shujun Zhao, Kaili Wang, Nan Zhang, Yun Tian, Yan Li, Yaping Wang, Xiaofeng Lv, Tianxiang Wei, Yan Liu, Suzhen Fan, Yang Liu, Yuan Li, Aojie Cai, Shuo Jin, Qiaohong Qin & Hongyu Li
Cell Death & Disease volume 10, (Web Link)

[5] Enyegue Elisée Libert, E., Mogtomo Martin Luther, K., Thomas, B., Ndeh Gilbert, D., Eloge, T., Foko Loick Pradel, K., Okoubalimba Eliane Vanessa, A., Elouki Landry, E., Sone Albert, M. and Ngane Annie Rosalie, N. (2017) “Dynamics of Factors Responsible for the Resurgence of Cervical Cancer Lesions in Women in Developing Countries”, Journal of Applied Life Sciences International, 11(2), (Web Link)

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