LATEST RESEARCH NEWS ON CANCER: FEB- 2020

Surgical resection with or without preoperative chemotherapy in oesophageal cancer: a randomised controlled trial

Background : The outlook for patients with oesophageal cancer undergoing surgical resection with curative intent is poor. We aimed to assess the effects of preoperative chemotherapy on survival, dysphagia, and performance status in this group of patients. [1]

The second British Stomach Cancer Group trial of adjuvant radiotherapy or chemotherapy in resectable gastric cancer: five-year follow-up

The overall survival in patients with gastric cancer is low, even among those undergoing resection. It has been hoped that the development of adjuvant therapy might improve survival in patients following surgery when tumour burden was minimal and both chemotherapy and radiotherapy have been proposed as suitable for use in gastric cancer. [2]

Fibroblasts in cancer

Tumours are known as wounds that do not heal — this implies that cells that are involved in angiogenesis and the response to injury, such as endothelial cells and fibroblasts, have a prominent role in the progression, growth and spread of cancers. [3]

Evaluation of Selected Natural Compounds for Cancer Stem Cells Targeted Anti-cancer Activity: A Molecular Docking Study

Aims: Cancer stem cells (CSCs) play significant roles in tumor initiation, relapse, angiogenesis, metastasis and therapy. Collectively Wnt, Notch, and Hedgehog are major pathways that have been linked to the drug resistance of CSCs. Eliminating CSCs has been suggested as a promising approach to cure cancer. Aim of the present study is screening of selected natural compounds for inhibitors of Wnt, and Hedgehog pathways that have been linked to the drug resistance of cancer stem cells (CSCs) by in silico molecular docking analysis. [4]

Molecular Therapeutic Cancer Peptides: A Closer Look at Bovine Lactoferricin

Background: In spite of the progress that was recorded in the development of anticancer drugs, challenges continue to rises particularly due to resistance of the cancer chemotherapies and low sensitivity of the commercially available anticancer drugs. Methodology: collection and review of available literatures. Results: Bovine lactoferricin (LfcinB) is a cationic peptide with broad spectrum antimicrobial and anticancer activity. It also shows promising activity against many varieties of cancer cells including colon carcinoma cells, melanoma, fibrosarcoma, monocytic leukemic cells and neuroblastoma. It is unaffected by multidrug resistance mechanisms seen with conventional chemotherapeutic drugs, [5]

Reference

[1] Working, M.R.C.O.C., 2002. Surgical resection with or without preoperative chemotherapy in oesophageal cancer: a randomised controlled trial. The Lancet359(9319), pp.1727-1733.

[2] Hallissey, M.T., Dunn, J.A., Ward, L.C., Allum, W.H. and Group, B.S.C., 1994. The second British Stomach Cancer Group trial of adjuvant radiotherapy or chemotherapy in resectable gastric cancer: five-year follow-up. The Lancet343(8909), pp.1309-1312.

[3] Kalluri, R. and Zeisberg, M., 2006. Fibroblasts in cancer. Nature Reviews Cancer6(5), pp.392-401.

[4] Mayan, K., Samarakoon, S.R., Tennekoon, K.H., Siriwardana, A. and Valverde, J.R., 2016. Evaluation of selected natural compounds for cancer stem cells targeted anti-cancer activity: a molecular docking study. European Journal of Medicinal Plants, pp.1-21.

[5] Sadiq, I. Z., Babagana, K., Danlami, D., Abdullahi, L. I. and Khan, A. R. (2018) “Molecular Therapeutic Cancer Peptides: A Closer Look at Bovine Lactoferricin”, Asian Journal of Biochemistry, Genetics and Molecular Biology, 1(2), pp. 1-9. doi: 10.9734/ajbgmb/2018/v1i2471.

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