News Update on Fatty Acid Research: Aug – 2019

Photoperoxidation in isolated chloroplasts: I. Kinetics and stoichiometry of fatty acid peroxidation

A photo-induced cyclic peroxidation in isolated chloroplasts is delineated . In associate degree diffusion buffered medium, chloroplasts upon illumination manufacture malondialdehyde (MDA)—a decomposition product of tri-unsaturated carboxylic acid hydroperoxides—bleach endogenous pigment, and consume gas. These processes show (a) no reaction within the absence of illumination; (b) associate degree initial lag part upon illumination of 10–20 minutes duration; (c) a linear introduce that the speed is proportional to the root of the sunshine intensity; (d) halt of reaction occurring among three minutes when illumination ceases; and (e) a termination part when many hours of illumination. [1]

Preparation of fatty acid methyl esters and dimethylacetals from lipids with boron fluoride–methanol

Fatty acid alkyl group esters and dimethylacetals appropriate for gas natural action analysis were ready by treatment of lipids with element fluoride–methanol (140 g BF3 per litre of methanol). This chemical agent is stable and simple to handle. Reaction conditions were investigated for triglycerides, diglycerides, monoglycerides, free fatty acids, steroid esters, phosphatidyl ethanolamines, phosphatidyl serines, phosphatidyl cholines, monophosphoinositides, monogalactosyl glycerides, phosphatidal cholines (choline plasmalogens), digalactosyl glycerides, and sphingomyelins. The alkyl group esters and dimethylacetals were pronto refined by thin-layer natural process, and yields were quantitative. [2]

TLR4 links innate immunity and fatty acid–induced insulin resistance

TLR4 is that the receptor for LPS and plays a vital role in immunity. Stimulation of TLR4 activates unhealthy pathways and induces protein expression during a style of cell sorts. Inflammatory pathways ar activated in tissues of rotund animals and humans and play a vital role in obesity-associated hormone resistance. Here we tend to show that nutritionary fatty acids, whose current levels ar usually raised in blubber, activate TLR4 signal in adipocytes and macrophages which the capability of fatty acids to induce inflammatory signal in fat cells or tissue and macrophages is dulled within the absence of TLR4. Moreover, mice lacking TLR4 ar considerably shielded from the power of general lipoid infusion to (a) suppress hormone signal in muscle and (b) cut back insulin-mediated changes in general aldohexose metabolism. [3]

Near-future ocean acidification does not alter the lipid content and fatty acid composition of adult Antarctic krill

Euphausia superba (Antarctic krill) could be a keystone species within the Southern Ocean, however very little is understood concerning however it’ll reply to global climate change. Ocean activity, caused by sequestration of CO2 into ocean surface waters (pCO2), alters the macromolecule organic chemistry of some organisms. this may have cascading effects up the organic phenomenon. in a very year-long laboratory experiment adult malacostracan crustacean were exposed to close H2O pCO2 levels (400 μatm), elevated pCO2 levels mimicking near-future ocean activity (1000, 1500 Associate in Nursingd 2000 μatm) and an extreme pCO2 level (4000 μatm). [4]

Fatty Acid Composition and Antimicrobial Activity of Baphia massaiensis Seed Oil

Aims: The seed oil composition of genus Baphia massaiensis seeds was firm mistreatment 1H proton magnetic resonance and GC-MS techniques. The seed oil was conjointly screened for antimicrobial activity.

Study Design: The study was designed to see genus Baphia massaiensis seed oil carboxylic acid composition and antimicrobial activity.

Place and length of Study: Department of Chemistry, University of Botswana, between June 2012 and Gregorian calendar month 2014. [5]

Reference

[1] Heath, R.L. and Packer, L., 1968. Photoperoxidation in isolated chloroplasts: I. Kinetics and stoichiometry of fatty acid peroxidation. Archives of biochemistry and biophysics, 125(1), pp.189-198. (Web Link)

[2] Morrison, W.R. and Smith, L.M., 1964. Preparation of fatty acid methyl esters and dimethylacetals from lipids with boron fluoride–methanol. Journal of lipid research, 5(4), pp.600-608. (Web Link)

[3] Shi, H., Kokoeva, M.V., Inouye, K., Tzameli, I., Yin, H. and Flier, J.S., 2006. TLR4 links innate immunity and fatty acid–induced insulin resistance. The Journal of clinical investigation, 116(11), pp.3015-3025. (Web Link)

[4] Near-future ocean acidification does not alter the lipid content and fatty acid composition of adult Antarctic krill
Jessica A. Ericson, Nicole Hellessey, So Kawaguchi, Peter D. Nichols, Stephen Nicol, Nils Hoem & Patti Virtue
Scientific Reportsvolume 9, Article number: 12375 (2019) (Web Link)

[5] Keroletswe, N., Mazimba, O., R. T. Majinda, R. and Masesane, I. (2017) “Fatty Acid Composition and Antimicrobial Activity of Baphia massaiensis Seed Oil”, Journal of Complementary and Alternative Medical Research, 2(3), pp. 1-7. doi: 10.9734/JOCAMR/2017/32553. (Web Link)

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