Latest Research on Mucormycosis Research: Sep – 2019

Mucormycosis

The term mucormycosis encompasses a particular cluster of infections caused by fungi happiness to genera inside the compartmentalisation order Mucorales, sometimes mold, Absidia, Mortierella, and Mucor. These fungi ar widespread in nature, subsisting on decaying vegetation and various organic materials. though the fungi and spores of fungus order show tokenish intrinsic pathogenicity toward traditional persons, they’ll initiate aggressive and sudden infections beneath sure clinical conditions. [1]

Epidemiology and Clinical Manifestations of Mucormycosis

Mucormycosis could be a extremely aggressive mycosis caused by class Zygomycetes, happiness to the taxonomic category Mucormycotina within the fungus order. This infection unremarkably presents Associate in Nursing aggressive and fast course and generally affects disorder patients. Mucormycosis will manifest in several clinical patterns and locations. though the proper identification is usually troublesome, early identification is crucial for patient survival. many clinical varieties of mucormycosis square measure recognised. connective tissue mucormycosis is a smaller amount common than alternative clinical forms, however doubtless deadly if treatment isn’t fast. [2]

Pulmonary Mucormycosis: The Last 30 Years

Pulmonary mucormycosis is comparatively uncommon however a crucial opportunist mycosis in upset persons. The literature on the topic is distributed. we have a tendency to describe a recent case and review the literature to delineate the clinical characteristics of this infection. we have a tendency to searched the telephone system info for articles printed within the English-language literature since 1970 and thoroughly analyzed eighty seven cases. the most risk factors were DM, haematological cancers, insufficiency, and organ transplantation. many patients had no apparent immune compromise. There was a predilection for involvement of the higher lobes. Air crescent signs on chest x-ray films were predictors of respiratory organ hemorrhage and death from haemoptysis. [3]

Mucormycosis in allogeneic bone marrow transplant recipients: report of five cases and review of the role of iron overload in the pathogenesis

In a 10-year consecutive series of 263 allogeneic bone marrow transplant recipients, we have a tendency to known 5 cases (1.9%) of invasive mucormycosis. just one infection occurred among the primary a hundred days once transplantation, whereas the rest sophisticated the late post-transplant course (median day of diagnosis: 343). Sites of infection were thought-about ‘non-classical’ and enclosed respiratory organ, connective tissue and internal organ involvement. No case of plant dissemination was determined. Mucormycosis was the first explanation for death in 3 of the 5 patients. Corticosteroid-treated graft-versus-host illness, either acute or chronic, or severe leukopenia were gift all told cases. [4]

Cutaneous Mucormycosis Following Trauma at the Surgical Site: A Rare Case

Mucormycosis may be a extremely aggressive zymosis caused by class Zygomycetes, happiness to the taxonomic group Mucormycotina within the Mucorales. This infection unremarkably presents Associate in Nursing aggressive and speedy course and generally affects upset patients. Mucormycosis will manifest in numerous clinical patterns and locations. though the right diagnosing is commonly troublesome, early identification is crucial for patient survival. many clinical sorts of mucormycosis are recognised. cutaneal mucormycosis is a smaller amount common than different clinical forms, however doubtless fatal if treatment isn’t speedy. [5]

Reference

[1] LEHRER, R.I., HOWARD, D.H., SYPHERD, P.S., EDWARDS, J.E., SEGAL, G.P. and WINSTON, D.J., 1980. Mucormycosis. Annals of Internal Medicine, 93(1_Part_1), (Web Link)

[2] Petrikkos, G., Skiada, A., Lortholary, O., Roilides, E., Walsh, T.J. and Kontoyiannis, D.P., 2012. Epidemiology and clinical manifestations of mucormycosis. Clinical Infectious Diseases, 54(suppl_1), (Web Link)

[3] Lee, F.Y., Mossad, S.B. and Adal, K.A., 1999. Pulmonary mucormycosis: the last 30 years. Archives of Internal Medicine, 159(12), pp.1301-1309. (Web Link)

[4] Mucormycosis in allogeneic bone marrow transplant recipients: report of five cases and review of the role of iron overload in the pathogenesis
J Maertens, H Demuynck, EK Verbeken, P Zachée, GEG Verhoef, P Vandenberghe & MA Boogaerts
Bone Marrow Transplantationvolume 24, pages307–312 (1999) (Web Link)

[5] Vidyavathi, B. C., Mahale, R. P. and Karthik, M. K. (2018) “Cutaneous Mucormycosis Following Trauma at the Surgical Site: A Rare Case”, International Journal of Medical and Pharmaceutical Case Reports, 11(2), (Web Link)

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