Latest Research on Hemoglobin Level: Jan – 2020

Hemoglobin Level Variability: Associations with Mortality

Background/objectives: Awareness of hemoglobin level variability in dialysis patients is increasing, as is interest in its potential implications. during this retrospective, national study of associations between the degree of hemoglobin level variability within the first 6 mo of 2004 and subsequent mortality rates within the following 6 mo, 159,720 hemodialysis patients receiving epoetin therapy were studied. Design, setting, participants, measurements: Monthly hemoglobin values were categorized as low (L; < 11 g/dl), intermediate (I; 11 to 12.5 g/dl), and high (H; >12.5 g/dl). Variability groups were classified on the idea of rock bottom and highest hemoglobin categories seen during the 6-mo observation period: low-low (L-L), 1.4%; intermediate-intermediate (I-I), 6.0%; high-high (H-H), 2.3%; low-intermediate (L-I), 18.3%; intermediate-high (I-H), 31.7%, and low-high (L-H), 40.2%. [1]

An Erythroid Enhancer of BCL11A Subject to Genetic Variation Determines Fetal Hemoglobin Level

Recent chromatin mapping data have suggested that trait-associated variants often mark regulatory DNA. However, there has been little rigorous experimental investigation of regulatory variation. Bauer et al. (p. 253; see the attitude by Hardison and Blobel) performed an in-depth study of the BCL11A fetal hemoglobin-associated locus. The trait-associated variants revealed a chromatin signature that enhanced erythroid development. The enhancer was required for erythroid expression of BCL11A and thus for globin organic phenomenon. [2]

Low Hemoglobin Level Is a Risk Factor for Postpartum Depression

The role of maternal anemia within the development of postpartum depression (PPD) is unclear. PPD may be a serious disorder which will negatively affect the physical and emotional health of a replacement mother and her infant. Although psychosocial factors that increase the danger of developing PPD are known, few studies have identified physiologic factors that predispose a lady to PPD. New mothers were visited reception on d 7, 14 and 28 after an uncomplicated labor and delivery. Hemoglobin (Hb) concentration was measured via finger-prick blood at each visit, and therefore the women completed the middle for Epidemiological Studies-Depressive Symptomatology Scale (CES-D) on d 28. There was a indirect correlation between Hb concentration on d 7 postpartum and depressive symptoms on d 28 (r = −4.26; P = 0.009). [3]

High hemoglobin levels are associated with decreased risk of diabetic retinopathy in Korean type 2 diabetes

Anemia is an independent risk factor for the event of diabetic retinopathy (DR) in patients with type 2 DM (DM). Hemoglobin levels can also be related to DR. We investigated the association between hemoglobin levels and DR risk. This cross-sectional, population-based study utilized data from 2,123 type 2 DM patients aged ≥30 years who participated within the Korea National Health and Nutrition Examination Survey from 2008 to 2012. Participants underwent an ophthalmic examination, including fundus photographs. A multiple logistic multivariate analysis was performed to guage the connection between hemoglobin levels and DR risk. [4]

Association of Delta-Aminolevulinic Acid Dehydratase Polymorphism with Blood Lead and Hemoglobin Level in Lead Exposed Workers

Introduction: Despite decades of intensive research, lead toxicity still remains one among the foremost health concerns. Hence, risks posed by lead are more likely to be determined by individual susceptibility as delta-aminolevulinic acid dehydratase (ALAD) gene can modify lead toxicokinetics.

Method: this study was aimed to guage the association of ALAD gene polymorphism (rs1800435 C/G) (ALAD 1-1, ALAD 1-2, ALAD 2-2) with blood lead level (BLL) and hemoglobin (Hb) content from 200 lead-exposed workers of Gujarat, India against 200 controls. [5]

Reference

[1] Gilbertson, D.T., Ebben, J.P., Foley, R.N., Weinhandl, E.D., Bradbury, B.D. and Collins, A.J., 2008. Hemoglobin level variability: associations with mortality. Clinical Journal of the American Society of Nephrology, 3(1), (Web Link)

[2] Bauer, D.E., Kamran, S.C., Lessard, S., Xu, J., Fujiwara, Y., Lin, C., Shao, Z., Canver, M.C., Smith, E.C., Pinello, L. and Sabo, P.J., 2013. An erythroid enhancer of BCL11A subject to genetic variation determines fetal hemoglobin level. Science, 342(6155), (Web Link)

[3] Corwin, E.J., Murray-Kolb, L.E. and Beard, J.L., 2003. Low hemoglobin level is a risk factor for postpartum depression. The Journal of nutrition, 133(12), (Web Link)

[4] High hemoglobin levels are associated with decreased risk of diabetic retinopathy in Korean type 2 diabetes
Min-Kyung Lee, Kyung-Do Han, Jae-Hyuk Lee, Seo-Young Sohn, Jee-Sun Jeong, Mee-Kyoung Kim, Ki-Hyun Baek, Ki-Ho Song & Hyuk-Sang Kwon
Scientific Reports volume 8, (Web Link)

[5] Nariya, A., Pathan, A., Shah, N., Patel, A., Chettiar, S., Vyas, J., Shaikh, I. and Jhala, D. (2017) “Association of Delta-Aminolevulinic Acid Dehydratase Polymorphism with Blood Lead and Hemoglobin Level in Lead Exposed Workers”, Annual Research & Review in Biology, 17(5), (Web Link)

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