Latest News on Cardiomyopathy Research: Jan – 2020

Hypertrophic Cardiomyopathy

(Second of Two Parts) Interrelation between Pathophysiologic Mechanisms and Disease ManifestationsSymptomsThe chief symptoms of cardiomyopathy are exertional angina, dyspnea, fatigue, and impaired consciousness (transient spells of lightheadedness, near-syncope, and syncope). However, a direct, one-to-one correlation between a specific symptom and one pathophysiologic mechanism doesn’t always exist. for instance , during a population of patients with cardiomyopathy , a general relation exists between the severity of symptoms and therefore the magnitude of left ventricular hypertrophy19; however, this correlation isn’t absolute, and a few patients with mild and localized hypertrophy may have severe symptoms,36 whereas other patients with. [1]

Diabetic Cardiomyopathy

Seventy-three patients with idiopathic primary myocardial disease, 16 of whom had DM , were compared to matched patients without cardiomyopathy. A statistically significant increase was observed within the frequency of diabetes in patients with idiopathic cardiomyopathy. Evolution of cardiomyopathy during a patient with preexisting diabetes and angina was also established. Four diabetic patients died; autopsies were performed on three. In these patients, the massive coronary arteries were patent and freed from arteriosclerosis, but small vessel changes were present within the myocardium. In contrast, autopsy findings in 28 patients who had cardiomyopathy without diabetes showed small coronary vessel disease in just one patient. [2]

Diabetic Cardiomyopathy Revisited

Diabetes mellitus increases the danger of coronary failure independently of underlying arteria coronaria disease, and lots of believe that diabetes results in cardiomyopathy. The underlying pathogenesis is partially understood. Several factors may contribute to the event of cardiac dysfunction within the absence of arteria coronaria disease in DM . This review discusses the newest findings in diabetic humans and in animal models and reviews emerging new mechanisms which will be involved within the development and progression of cardiac dysfunction in diabetes. [3]

Arrhythmogenic Left Ventricular Cardiomyopathy: A Clinical and CMR Study

The clinical features, CMR characteristics and outcomes of arrhythmogenic left ventricular cardiomyopathy (ALVC), which may be a very rare nonischemic cardiomyopathy, are currently not well studied. the aim of the study is to research the clinical and cardiovascular resonance (CMR) imaging characteristics of arrhythmogenic left ventricular cardiomyopathy (ALVC). Fifty-three consecutive patients with ALVC were divided into two groups: ALVC patients without right ventricular (RV) involvement (n = 36, group 1) and people with RV involvement (n = 17, group 2). Clinical symptoms, cardiac electrophysiological findings, and CMR parameters (morphology, ventricular function, and myocardial fibrosis and fatty infiltration) were evaluated in both groups. [4]

Acute Limb Ischemia Due to Cardiac Thromboembolismin a Young Patient without Myocardial Infarction or Cardiomyopathy

Acute limb ischemia secondary to systemic arterial embolism from left ventricular thrombus may be a rare life threatening emergency. Peripheral arterial thrombosis superimposed on an atherosclerotic disease or thromboembolism from cardiac or aortic source are the 2 commonest causes of acute limb ischemia. We present a case of a young healthy female who had recurrent admissions with acute lower extremity ischemia secondary to embolism from intra cardiac thrombus diagnosed by bedside doppler and computed angiogram, managed by surgical thromboembolectomy and discharge on anticoagulation. [5]

Reference

[1] Maron, B.J., Bonow, R.O., Cannon III, R.O., Leon, M.B. and Epstein, S.E., 1987. Hypertrophic cardiomyopathy. New England Journal of Medicine, 316(14), (Web Link)

[2] Hamby, R.I., Zoneraich, S. and Sherman, L., 1974. Diabetic cardiomyopathy. Jama, 229(13), (Web Link)

[3] Boudina, S. and Abel, E.D., 2007. Diabetic cardiomyopathy revisited. Circulation, 115(25), (Web Link)

[4] Arrhythmogenic Left Ventricular Cardiomyopathy: A Clinical and CMR Study
Jian He, Jing Xu, Guozhong Li, Di Zhou, Shuang Li, Baiyan Zhuang, Xiuyu Chen, Xuejin Duan, Li Li, Xiaohan Fan, Jinghan Huang, Gang Yin, Yong Jiang, Yang Wang, Shihua Zhao & Minjie Lu
Scientific Reports volume 10, (Web Link)

[5] Khalid, M., Murtaza, G., Albalbissi, A., Bochis, M. and K. Paul, T. (2018) “Acute Limb Ischemia Due to Cardiac Thromboembolismin a Young Patient without Myocardial Infarction or Cardiomyopathy”, Cardiology and Angiology: An International Journal, 7(3), (Web Link)

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